[The convulsive activity of white rats after immunization with a conjugate of sidnofen and serum albumin]. / Sudorozhnaia aktivnost' belykh krys posle immunizatsii kon''iugatom sidnofena s serumal'buminom.

The influence of white rats immunization by a covalent conjugate of serum albumin with sydnophen on the seizure activity in the single and repeated injections of pentylenetetrazole was investigated. The immunization lowered the seizure activity in single injections of threshold doses, (60 mg/kg) of pentylenetetrazole. The repeated daily injections of the drug in subthreshold doses (30 mg/kg) inhibited the process of "kindling" effects formation.

Active immunization against bioregulators: behavioural and catecholamine changes in albino rats immunized against sydnophen.

Active immunization of white rats against the catecholamine analogue, sydnophen, results in physiological changes extending over two months. The levels of noradrenaline in blood, and dopamine in brain, were depressed, some behavioural activities were reduced and alcohol consumption was lowered. On this basis, active immunization against various bioregulators--a method of inverse regulation--shows promise as a method for achieving long-term adjustment of physiological status.

[The immunization of white rats with a covalent conjugate of sidnofen and serum albumin suppresses chronic ethanol consumption]. / Immunizatsiia belykh krys kovalentnym kon''iugatom sidnofena s serumal'buminom podavliaet khronicheskoe potreblenie étanola.

The influence of white rats of alcohol abuse formation of immunization by covalent conjugates of serum albumin with psychostimulant sydnophen was investigated. Immunization by conjugates where the molar sydnophen: protein ratio was 18:1-33: 1 results in significant depression of 15% ethanol consumption (in the condition of free choice between water and ethanol solution).

[Immunocorrection of the physiologic status of white rats by sidnofen conjugates with bovine serum albumin]. / Immunokorrektsiia fiziologicheskogo statusa belykh krys kon''iugatami sidnofena s bych'im syvorotochnym al'buminom.

The effect of immunisation by covalent conjugates of known psychostimulant and antidepressant sydnophen with bovine serum albumin (BSA) on behaviour, formation of conditioned reflex reactions and alcoholization of white rats has been studied. The immunization of sydnophen with BSA by conjugates permits to obtain a long-term alteration of the emotional status: suppression of behavioral activity, learning and alcohol attraction of rats similar in some elements to the action of neuroleptic drugs. The direction of these alterations is opposite to ones caused by the action of sydnophen. It gives possibility to consider fruitful the conception on the ways of long-term immunocorrection of the physiological status of organism.

[Immunostimulating and antitumor action of psychotropic preparations of the sydnonimine series]. / Ob immunostiomuliruiushchem i protivoopukholevom deistvii nekotorykh psikhotropnykh preparatov sidnoniminovogo riada.

In healthy animals and in those with different experimental tumours, the psychostimulant drug sydnophen activates the immune reactions: increases the number of RFC, the intensity of delayed hypersensitivity, blast transformation of lymphocytes, and the QD coefficient. This activation is attended by a slight inhibition of transplanted tumours. The psychostimulant sydnocarb exerts no immunostimulant action or any effect on the growth of experimental tumours.